Synthesis and Biological Activity of the Pinostrobin Oxime Complex Compounds with Some d-Metals
A. A. Mashentsevaa, T. S. Seytembetova, S. M. Adekenovb, B. I. Tuleuovb, O. P. Loikoc, and A. I. Khalitovac
a L.N. Gumilyov Eurasian National University, Munaitpasova Str. 5, Astana, 010008 Kazakhstan
b International Holding “Phytochemistry,” Karaganda, Kazakhstan
c Buketov Karaganda State University, Karaganda, Kazakhstan
Received September 6, 2010
Abstract―The process of the complex formation by the natural flavonoid pinostrobin (5-hydroxy-7-methoxyflavonone) oxime with the Cu(II) and Fe(III) ions in a water–ethanol medium was investigated. The metal : ligand ratio in the complex was determined by the saturation method. The results of the analysis of IR spectra and the data of mass-spectrometric studies of the structure of the obtained complex compounds are reported. The antiviral activity of the synthesized complexes with respect to the human immunodeficiency virus HIV-1 IIIB and HIV-2 ROD strains was studied. The antioxidant activity of the complexes, as well as the parent pinostrobin oxime ligand, was evaluated with respect to the diphenylpicrylhydrazyl (DPPH) radical and the 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid (ABTS) radical cation.