Molecular genetic studies and development of a rapid test for the detection of antigens of dermatophytes to improve diagnosis of onychomycosis.
Relevance of the project: development of a complete collection of dermatomycoses originators and laboratory diagnosis and rapid diagnosis.
Objectives: study of species diversity of onychomycosis originators of residents of Astana; study of phenotypic and genotypic characteristics of dermatophytes using multilocus sequence typing; creation of a collection of microbial originators of onychomycosis of humans, producing specific antigens, valuable in respect of diagnostics.
Scientific novelty: creation of a collection of microbial originators of onychomycosis of humans producing specific antigens, valuable in respect of diagnostics.
Production of a biomass, separation and purification of Trichophyton rubrum and Trichophyton mentagrophytes antigens.
Study of properties, activity, specificity and immunogenicity, definition of working titres of antigens in various serotests.
Scope of Application
The project is executed over the program of the Ministry of Education and Science of the Republic of Kazakhstan “Grant financing of scientific research” for 2012-2014 (7 000 thousand tenge for 2012).